Fairly accurate determination of VLDL & LDL can be done for the values of cholesterol less than 400 mg/dl, by using the following formulae based on “The Friedewald equation”.

Determine-

   a) Total cholesterol

   b) HDL- cholesterol and

   c) T.G.

Then calculate VLDL and LDL as follows:

VLDL (mg/dl)                      =          Triglyceride/5

LDL-cholesterol (mg/dl)    =          Total Cholesterol – HDL – VLDL

 Normal Value:-

VLDL                =          2 – 38 mg/dl

 LDL                  =          < 130 mg/dl

Clinical Significance:-

This test measures the amount of very low-density lipoprotein (VLDL) in your blood. VLDL cholesterol is a type of blood fat. It’s considered one of the “bad” forms of cholesterol, along with LDL cholesterol and
triglycerides. This is because high levels cholesterol can clog your arteries and lead to a heart attack.

High levels of LDL (low-density lipoprotein) cholesterol are associated with an increased risk of atherosclerosis, which can lead to other health conditions like stroke, coronary artery disease, and peripheral arterial disease